The free radical scavenger Trolox dampens neuronal hyperexcitability, reinstates synaptic plasticity, and improves hypoxia tolerance in a mouse model of Rett syndrome
Rett syndrome (RS) causes Nappy Bin severe cognitive impairment, loss of speech, epilepsy, and breathing disturbances with intermittent hypoxia.Also mitochondria are affected; a subunit of respiratory complex III is dysregulated, the inner mitochondrial membrane is leaking protons, and brain ATP levels seem reduced.Our recent assessment of mitochon